Orlistat (Xenical) is a lipase inhibitor used to reduce weight and prevent weight gain. Orlistat is prescribed for obese people who have health problems such as diabetes, high blood pressure, or high cholesterol. Orlistat blocks the absorption of dietary fat into the bloodstream, thereby reducing the number of calories from food. You can use Orlistat with diet and exercise to get more benefits.
Orlistat is a reversible inhibitor of gastrointestinal lipases. It acts in the lumen of the stomach and small intestine, forming a covalent bond with the active center of the serine residue of gastric and pancreatic lipases. Inactivated enzymes are unable to hydrolyze dietary fats in the form of triglycerides into absorbable free fatty acids and monoglycerides. Since undigested triglycerides are not absorbed, the resulting calorie deficit has a positive effect on weight.
The effect of orlistat was assessed by the proportion of fat excreted in the feces, received with food. At the recommended therapeutic dose of 120 mg 3 times daily, orlistat inhibits dietary fat absorption by approximately 30%. Ethanol does not affect orlistat’s ability to prevent fat absorption.
Buy Orlistat (Xenical) online
Several studies have evaluated the effect of therapeutic doses of orlistat on gastrointestinal and systemic physiological processes in normal weight and obese adults. There were no clinically significant changes in gallbladder motility, bile composition, colonic cell proliferation rate, or a clinically significant reduction in gastric emptying time. In addition, no effect of orlistat on plasma triglyceride levels or systemic lipases was observed in these studies. Orlistat at a dose of 120 mg 3 times a day does not significantly affect the balance of trace elements – calcium, magnesium, phosphorus, zinc, copper, and iron.
Systemic exposure to orlistat is minimal. A mass balance study in obese patients treated with orlistat orally showed two metabolites, M1 (hydrolysis product of the β-lactone ring of orlistat) and M3 (formed after cleavage of the N-formylleucine side chain). Due to weak inhibitory activity and low plasma levels, these metabolites are considered pharmacologically insignificant. The main route of elimination of orlistat is the excretion of the drug with feces. The time to achieve complete elimination ranged from 3 to 5 days.
Take Orlistat by mouth three times a day during (or within an hour of) each main meal containing fat. You should take a multivitamin supplement containing vitamins A, D, E, and K at least two hours before or after taking this medicine.
The recommended dose for adults is 1 capsule of 120 mg 3 times a day.
Do not take this medicine without consulting your doctor. Do not use Orlistat if you have kidney stones, are taking cyclosporine, or other weight loss drugs. Weight loss starts within two weeks. The effect of using Orlistat for more than 2 years is still unknown. If you have diabetes, losing weight can lower your blood sugar levels. Talk to your doctor about Orlistat dosage if you are taking oral diabetes medication or insulin. Orlistat should not be used during pregnancy, early pregnancy or while breastfeeding.
If you forget to take your dose on time, do so as soon as you remember. But don’t take it if it’s too late or almost time for your next dose. Do not increase the recommended dose. Take your usual dose the next day at the same usual time.
Buy Orlistat without a prescription
After oral administration, Orlistat is practically not absorbed from the gastrointestinal tract. After taking therapeutic doses, unchanged Orlistat was determined in blood plasma only in rare cases (as a result of long-term treatment), its concentrations were extremely low. There were no signs of cumulation, which indicates a minimal absorption of the drug.
The metabolism of Xenical occurs mainly at the presystemic level. Given the low activity and low plasma concentrations after administration of therapeutic doses, these metabolites are considered pharmacologically inactive. 97% of the accepted dose of Xenical is excreted in the feces, of which 83% is unchanged. The period of complete elimination of the drug from the body (together with feces and urine) is 3-5 days.
Xenical is a potent long-acting specific inhibitor of gastrointestinal lipases. Its therapeutic effect is manifested in the lumen of the stomach and small intestine. An inactivated enzyme loses its ability to break down dietary fat in the form of triglycerides into usable free fatty acids. Since undigested fat is not absorbed, there is a decrease in the number of calories entering the body, and therefore a decrease in body weight. Thus, the therapeutic effect of the drug is achieved without its absorption into the systemic circulation.
The effect of the drug is manifested within 24-48 hours after administration. After stopping the drug, the fat content of feces usually returns to its original level (before treatment) after 48-72 hours.
Weight loss in obese patients is observed as early as 2 weeks after the start of treatment and occurs due to subcutaneous fat. Taking the drug reduces the risk of weight gain after weight loss after other types of treatment. In patients with type 2 diabetes, weight loss associated with the use of Xenical leads to an improvement in carbohydrate metabolism.
Orlistat – a possible side effects
They can include all kinds of allergic reactions. Stop taking Orlistat immediately if you experience severe upper stomach pain that radiates to your back, nausea and vomiting, and a fast heartbeat. The most possible side effects also include:
- oily stains on underwear;
- fatty stool;
- orange or brown oil in the stool;
- loose stools or an urgent need to go to the toilet, inability to control bowel movements;
- increased defecation;
- abdominal pain, nausea, diarrhea, rectal pain;
- loss of appetite, weakness, dark urine, itching, or jaundice.
Less serious include:
- cold symptoms such as nasal congestion, sneezing, cough;
- fever, chills, sore throat, flu-like symptoms;
- headaches, back pain;
- mild rash.
If you experience any of these effects, stop using Orlistat and talk to your doctor. Also, check with your doctor for any side effects that seem unusual.
One 120 mg capsule with each main meal (during meals or no later than one hour after meals). If a meal is skipped or the food does not contain fat, the medicine can also be skipped. Throughout the duration of the treatment, it is recommended to follow a balanced, moderately low-calorie diet, composed of 30% fat. The consumption of fruits and vegetables is recommended. The daily rate of fat, protein, and carbohydrates should be divided into 3 main meals.
Taking a higher dose than recommended (120 mg 3 times a day) does not increase the therapeutic effect.